Nanotechnology for biomaterials engineering: Structural characterization of amphiphilic polymeric nanoparticles by 1H NMR spectroscopy

Jeffrey S. Hrkach, Maria Teresa Peracchia, Avi Domb, Noah Lotan, Robert Langer

Research output: Contribution to journalArticlepeer-review

185 Scopus citations

Abstract

Nanoparticles composed of diblock poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) or a branched, multiblock PLA-(PEG)3 were prepared by the single emulsion technique. Results of previous studies of these nanoparticles suggested that their structure is of the core-corona type with a polyester core and an outer PEG coating. In the present study, 1H NMR spectroscopy was utilized to provide direct evidence of the structure of these nanoparticles suspended in an aqueous environment. The results confirm the existence of the core-corona structure under these conditions, and show that the PEG moieties extend out from the nanoparticle core into the aqueous environment, and exhibit chain mobility similar to that of PEG in solution.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalBiomaterials
Volume18
Issue number1
DOIs
StatePublished - Jan 1997
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by NIH grant GM26698 NSF grant BCS-9202311.

Keywords

  • Biodegradable nanoparticles
  • NMR
  • Nanotechnology
  • Spectroscopy
  • Structural characterization

Fingerprint

Dive into the research topics of 'Nanotechnology for biomaterials engineering: Structural characterization of amphiphilic polymeric nanoparticles by 1H NMR spectroscopy'. Together they form a unique fingerprint.

Cite this