Nanostructured medical sutures with antibacterial properties

Cristina Serrano; Luis García-Fernández; Juan Pedro Fernández-Blázquez; Mike Barbeck; Shahram Ghanaati; Ron Unger; James Kirkpatrick; Eduard Arzt; Lutz Funk; Pau Turón; Aránzazu del Campo

doi:10.1016/j.biomaterials.2015.02.039

Nanostructured medical sutures with antibacterial properties

Cristina Serrano, Luis García-Fernández, Juan Pedro Fernández-Blázquez, Mike Barbeck, Shahram Ghanaati, Ron Unger, James Kirkpatrick, Eduard Arzt, Lutz Funk, Pau Turón, Aránzazu del Campo

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Bacterial repellence in suture materials is a desirable property that can potentially improve the healing process by preventing infection. We describe a method for generating nanostructures at the surface of commercial sutures of different composition, and their potential for preventing biofilm formation. We show how bacteria attachment is altered in the presence of nanosized topographies and identify optimum designs for preventing it without compromising biocompatibility and applicability in terms of nanostructure robustness or tissue friction. These studies open new possibilities for flexible and cost-effective realization of topography-based antibacterial coatings for absorbable biomedical textiles.

Original language	English
Pages (from-to)	291-300
Number of pages	10
Journal	Biomaterials
Volume	52
Issue number	1
DOIs	https://doi.org/10.1016/j.biomaterials.2015.02.039
State	Published - Jun 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

Funding

Authors acknowledge financial support from BMBF (FixNaht, FKZ 13EZ1105 ) and thank Dr. Rüdiger Berger (MPI-P, Mainz) for AFM measurements.

Funders	Funder number
Bundesministerium für Bildung und Forschung	FKZ 13EZ1105

Keywords

Antibacterial
Antifouling
Nanopatterning
Plasma treatment
Sutures

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10.1016/j.biomaterials.2015.02.039

Cite this

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title = "Nanostructured medical sutures with antibacterial properties",

abstract = "Bacterial repellence in suture materials is a desirable property that can potentially improve the healing process by preventing infection. We describe a method for generating nanostructures at the surface of commercial sutures of different composition, and their potential for preventing biofilm formation. We show how bacteria attachment is altered in the presence of nanosized topographies and identify optimum designs for preventing it without compromising biocompatibility and applicability in terms of nanostructure robustness or tissue friction. These studies open new possibilities for flexible and cost-effective realization of topography-based antibacterial coatings for absorbable biomedical textiles.",

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AU - Unger, Ron

AU - Kirkpatrick, James

AU - Arzt, Eduard

AU - Funk, Lutz

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Nanostructured medical sutures with antibacterial properties

Abstract

Bibliographical note

Funding

Keywords

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