TY - JOUR
T1 - Nanometric agents in the service of neuroscience
T2 - Manipulation of neuronal growth and activity using nanoparticles
AU - Polak, Pazit
AU - Shefi, Orit
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/8
Y1 - 2015/8
N2 - Nerve regeneration and recovery could provide great therapeutic benefits for individuals suffering from nerve damage post trauma or degenerative diseases. However, manipulation of nerves presents a huge challenge for neuroscientists and is not yet clinically feasible. In recent years, nanoparticles have emerged as novel effective agents for control of neuronal growth and behavior. Nanoparticles may facilitate the needed nerve manipulation abilities for therapeutic and diagnostic purposes including within the brain. This review aims at presenting the currently available literature regarding the interactions between inorganic nanoparticles and neurons. A wide range of nanoparticles are presented, including gold, iron oxide, cerium oxide, nanotubes and quantum-dots. The nanoparticles enhance neuronal differentiation and survival, direct growth and regulate electrical activity. The studies are summarized in a concise table, arranged by the function and type of nanoparticle. The latest studies present a novel interdisciplinary approach, which could be harnessed for clinical applications in nanomedicine. From the Clinical Editor: Nerve regeneration remains the Holy Grail for patients with neuron loss. Nonetheless, this goal has not been realized in clinical setting thus far. In this article, the authors present a comprehensive review on various nanoparticle-based approaches, in both diagnosis and therapy, which should stimulate and generate more research ideas to the advancement in this field.
AB - Nerve regeneration and recovery could provide great therapeutic benefits for individuals suffering from nerve damage post trauma or degenerative diseases. However, manipulation of nerves presents a huge challenge for neuroscientists and is not yet clinically feasible. In recent years, nanoparticles have emerged as novel effective agents for control of neuronal growth and behavior. Nanoparticles may facilitate the needed nerve manipulation abilities for therapeutic and diagnostic purposes including within the brain. This review aims at presenting the currently available literature regarding the interactions between inorganic nanoparticles and neurons. A wide range of nanoparticles are presented, including gold, iron oxide, cerium oxide, nanotubes and quantum-dots. The nanoparticles enhance neuronal differentiation and survival, direct growth and regulate electrical activity. The studies are summarized in a concise table, arranged by the function and type of nanoparticle. The latest studies present a novel interdisciplinary approach, which could be harnessed for clinical applications in nanomedicine. From the Clinical Editor: Nerve regeneration remains the Holy Grail for patients with neuron loss. Nonetheless, this goal has not been realized in clinical setting thus far. In this article, the authors present a comprehensive review on various nanoparticle-based approaches, in both diagnosis and therapy, which should stimulate and generate more research ideas to the advancement in this field.
KW - Nanoparticles
KW - Nanotechnology
KW - Neuronal-activity
KW - Neuronal-growth
KW - Neurons
UR - http://www.scopus.com/inward/record.url?scp=84937138778&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2015.03.005
DO - 10.1016/j.nano.2015.03.005
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C2 - 25819887
AN - SCOPUS:84937138778
SN - 1549-9634
VL - 11
SP - 1467
EP - 1479
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
IS - 6
ER -