Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells

Jianmin Xu, Tara Teslaa, Ting Hsiang Wu, Pei Yu Chiou, Michael A. Teitell, Shimon Weiss

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Quantum dots (QDs) have not been used to label cytoskeleton structure of live cells owing to limitations in delivery strategies, and QDs conjugation methods and issues with nonspecific binding. We conjugated tubulin to QDs and applied the emerging method of photothermal nanoblade to deliver QD-tubulin conjugates into live Hela cells. This method will open new opportunities for cytosolic targeting of QDs in live cells.

Original languageEnglish
Pages (from-to)5669-5672
Number of pages4
JournalNano Letters
Volume12
Issue number11
DOIs
StatePublished - 14 Nov 2012
Externally publishedYes

Funding

FundersFunder number
National Institute of Biomedical Imaging and BioengineeringR01EB000312

    Keywords

    • Nanoblade delivery
    • QD-tubulin
    • cytosolic targeting

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