TY - JOUR
T1 - Nano- and microparticles as adjuvants in vaccine design
T2 - Success and failure is related to host natural antibodies
AU - Sinyakov, Michael S.
AU - Dror, Moti
AU - Lublin-Tennenbaum, Tammy
AU - Salzberg, Samuel
AU - Margel, Shlomo
AU - Avtalion, Ramy R.
PY - 2006/10/30
Y1 - 2006/10/30
N2 - Bovine serum albumin (BSA) and the surface A-layer protein (AP) of an atypical strain of fish bacterial pathogen Aeromonas salmonicida were covalently linked with polymeric nano- and microparticles, and antigenicity of the resulted conjugates was compared in mice and goldfish. Distinct albeit different levels of natural BSA and AP antibodies were present in both animal species. Significant stimulation of the anti-AP antibody response in mice strikingly contrasted to unresponsiveness or even suppression in fish. The results negatively correlate with the levels of respective natural antibodies in the host and are discussed in context of problems related to fish vaccination. The work reinforces the instructive role of natural antibodies in adaptive immune response.
AB - Bovine serum albumin (BSA) and the surface A-layer protein (AP) of an atypical strain of fish bacterial pathogen Aeromonas salmonicida were covalently linked with polymeric nano- and microparticles, and antigenicity of the resulted conjugates was compared in mice and goldfish. Distinct albeit different levels of natural BSA and AP antibodies were present in both animal species. Significant stimulation of the anti-AP antibody response in mice strikingly contrasted to unresponsiveness or even suppression in fish. The results negatively correlate with the levels of respective natural antibodies in the host and are discussed in context of problems related to fish vaccination. The work reinforces the instructive role of natural antibodies in adaptive immune response.
KW - Acquired antibodies
KW - Aeromonas salmonicida
KW - Natural antibodies
UR - http://www.scopus.com/inward/record.url?scp=33749446992&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2006.06.021
DO - 10.1016/j.vaccine.2006.06.021
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C2 - 16842893
AN - SCOPUS:33749446992
SN - 0264-410X
VL - 24
SP - 6534
EP - 6541
JO - Vaccine
JF - Vaccine
IS - 42-43
ER -
