N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk

Yael Leitner-Dagan; Ziv Sevilya; Mila Pinchev; Ran Kramer; Dalia Elinger; Laila C. Roisman; Hedy S. Rennert; Edna Schechtman; Laurence Freedman; Gad Rennert; Zvi Livneh; Tamar Paz-Elizur

doi:10.1093/jnci/djs445

N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk

Yael Leitner-Dagan
, Ziv Sevilya
, Mila Pinchev
, Ran Kramer
, Dalia Elinger
, Laila C. Roisman
, Hedy S. Rennert
, Edna Schechtman
, Laurence Freedman
, Gad Rennert
, Zvi Livneh
, Tamar Paz-Elizur

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.

Original language	English
Pages (from-to)	1765-1769
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	104
Issue number	22
DOIs	https://doi.org/10.1093/jnci/djs445
State	Published - 21 Nov 2012
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported the Early Detection Research Network of the National Cancer Institute, National Institutes of Health (U01 CA111219 to ZL, TP-E, and GR) and the Flight Attendant Medical Research Institute, Florida (part of a Center of Excellence Award, 032001 to ZL and TP-E).

Funding

This work was supported the Early Detection Research Network of the National Cancer Institute, National Institutes of Health (U01 CA111219 to ZL, TP-E, and GR) and the Flight Attendant Medical Research Institute, Florida (part of a Center of Excellence Award, 032001 to ZL and TP-E).

Funders	Funder number
National Institutes of Health
National Cancer Institute	U01CA111219
Flight Attendant Medical Research Institute	032001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1093/jnci/djs445

Cite this

Leitner-Dagan, Y., Sevilya, Z., Pinchev, M., Kramer, R., Elinger, D., Roisman, L. C., Rennert, H. S., Schechtman, E., Freedman, L., Rennert, G., Livneh, Z., & Paz-Elizur, T. (2012). N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk. Journal of the National Cancer Institute, 104(22), 1765-1769. https://doi.org/10.1093/jnci/djs445

@article{4177614806b34ad9af71fcbfb977760d,

title = "N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk",

abstract = "Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95\% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95\% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.",

author = "Yael Leitner-Dagan and Ziv Sevilya and Mila Pinchev and Ran Kramer and Dalia Elinger and Roisman, \{Laila C.\} and Rennert, \{Hedy S.\} and Edna Schechtman and Laurence Freedman and Gad Rennert and Zvi Livneh and Tamar Paz-Elizur",

note = "Funding Information: This work was supported the Early Detection Research Network of the National Cancer Institute, National Institutes of Health (U01 CA111219 to ZL, TP-E, and GR) and the Flight Attendant Medical Research Institute, Florida (part of a Center of Excellence Award, 032001 to ZL and TP-E).",

year = "2012",

month = nov,

day = "21",

doi = "10.1093/jnci/djs445",

language = "אנגלית",

volume = "104",

pages = "1765--1769",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "22",

}

Leitner-Dagan, Y, Sevilya, Z, Pinchev, M, Kramer, R, Elinger, D, Roisman, LC, Rennert, HS, Schechtman, E, Freedman, L, Rennert, G, Livneh, Z & Paz-Elizur, T 2012, 'N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk', Journal of the National Cancer Institute, vol. 104, no. 22, pp. 1765-1769. https://doi.org/10.1093/jnci/djs445

TY - JOUR

T1 - N-methylpurine DNA glycosylase and OGG1 DNA repair activities

T2 - Opposite associations with lung cancer risk

AU - Leitner-Dagan, Yael

AU - Sevilya, Ziv

AU - Pinchev, Mila

AU - Kramer, Ran

AU - Elinger, Dalia

AU - Roisman, Laila C.

AU - Rennert, Hedy S.

AU - Schechtman, Edna

AU - Freedman, Laurence

AU - Rennert, Gad

AU - Livneh, Zvi

AU - Paz-Elizur, Tamar

N1 - Funding Information: This work was supported the Early Detection Research Network of the National Cancer Institute, National Institutes of Health (U01 CA111219 to ZL, TP-E, and GR) and the Flight Attendant Medical Research Institute, Florida (part of a Center of Excellence Award, 032001 to ZL and TP-E).

PY - 2012/11/21

Y1 - 2012/11/21

N2 - Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.

AB - Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.

UR - https://www.scopus.com/pages/publications/84870158807

U2 - 10.1093/jnci/djs445

DO - 10.1093/jnci/djs445

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 23104324

AN - SCOPUS:84870158807

SN - 0027-8874

VL - 104

SP - 1765

EP - 1769

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 22

ER -

N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk

Abstract

Bibliographical note

Funding

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this