N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk

Yael Leitner-Dagan; Ziv Sevilya; Mila Pinchev; Ran Kramer; Dalia Elinger; Laila C. Roisman; Hedy S. Rennert; Edna Schechtman; Laurence Freedman; Gad Rennert; Zvi Livneh; Tamar Paz-Elizur

doi:10.1093/jnci/djs445

N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk

Yael Leitner-Dagan, Ziv Sevilya, Mila Pinchev, Ran Kramer, Dalia Elinger, Laila C. Roisman, Hedy S. Rennert, Edna Schechtman, Laurence Freedman, Gad Rennert, Zvi Livneh, Tamar Paz-Elizur

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Abstract

Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.

Original language	English
Pages (from-to)	1765-1769
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	104
Issue number	22
DOIs	https://doi.org/10.1093/jnci/djs445
State	Published - 21 Nov 2012
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported the Early Detection Research Network of the National Cancer Institute, National Institutes of Health (U01 CA111219 to ZL, TP-E, and GR) and the Flight Attendant Medical Research Institute, Florida (part of a Center of Excellence Award, 032001 to ZL and TP-E).

Funding

This work was supported the Early Detection Research Network of the National Cancer Institute, National Institutes of Health (U01 CA111219 to ZL, TP-E, and GR) and the Flight Attendant Medical Research Institute, Florida (part of a Center of Excellence Award, 032001 to ZL and TP-E).

Funders	Funder number
National Institutes of Health
National Cancer Institute	U01CA111219
Flight Attendant Medical Research Institute	032001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jnci/djs445

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Leitner-Dagan, Y., Sevilya, Z., Pinchev, M., Kramer, R., Elinger, D., Roisman, L. C., Rennert, H. S., Schechtman, E., Freedman, L., Rennert, G., Livneh, Z., & Paz-Elizur, T. (2012). N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk. Journal of the National Cancer Institute, 104(22), 1765-1769. https://doi.org/10.1093/jnci/djs445

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title = "N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk",

abstract = "Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.",

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note = "Funding Information: This work was supported the Early Detection Research Network of the National Cancer Institute, National Institutes of Health (U01 CA111219 to ZL, TP-E, and GR) and the Flight Attendant Medical Research Institute, Florida (part of a Center of Excellence Award, 032001 to ZL and TP-E).",

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Leitner-Dagan, Y, Sevilya, Z, Pinchev, M, Kramer, R, Elinger, D, Roisman, LC, Rennert, HS, Schechtman, E, Freedman, L, Rennert, G, Livneh, Z & Paz-Elizur, T 2012, 'N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk', Journal of the National Cancer Institute, vol. 104, no. 22, pp. 1765-1769. https://doi.org/10.1093/jnci/djs445

TY - JOUR

T1 - N-methylpurine DNA glycosylase and OGG1 DNA repair activities

T2 - Opposite associations with lung cancer risk

AU - Leitner-Dagan, Yael

AU - Sevilya, Ziv

AU - Pinchev, Mila

AU - Kramer, Ran

AU - Elinger, Dalia

AU - Roisman, Laila C.

AU - Rennert, Hedy S.

AU - Schechtman, Edna

AU - Freedman, Laurence

AU - Rennert, Gad

AU - Livneh, Zvi

AU - Paz-Elizur, Tamar

N1 - Funding Information: This work was supported the Early Detection Research Network of the National Cancer Institute, National Institutes of Health (U01 CA111219 to ZL, TP-E, and GR) and the Flight Attendant Medical Research Institute, Florida (part of a Center of Excellence Award, 032001 to ZL and TP-E).

PY - 2012/11/21

Y1 - 2012/11/21

N2 - Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.

AB - Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.

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N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk

Abstract

Bibliographical note

Funding

UN SDGs

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