TY - JOUR
T1 - N-methylpurine DNA glycosylase and OGG1 DNA repair activities
T2 - Opposite associations with lung cancer risk
AU - Leitner-Dagan, Yael
AU - Sevilya, Ziv
AU - Pinchev, Mila
AU - Kramer, Ran
AU - Elinger, Dalia
AU - Roisman, Laila C.
AU - Rennert, Hedy S.
AU - Schechtman, Edna
AU - Freedman, Laurence
AU - Rennert, Gad
AU - Livneh, Zvi
AU - Paz-Elizur, Tamar
N1 - Funding Information:
This work was supported the Early Detection Research Network of the National Cancer Institute, National Institutes of Health (U01 CA111219 to ZL, TP-E, and GR) and the Flight Attendant Medical Research Institute, Florida (part of a Center of Excellence Award, 032001 to ZL and TP-E).
PY - 2012/11/21
Y1 - 2012/11/21
N2 - Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.
AB - Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] 1.2 to 2.6; P . 006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI 1.4 to 3.6; P <. 001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.
UR - http://www.scopus.com/inward/record.url?scp=84870158807&partnerID=8YFLogxK
U2 - 10.1093/jnci/djs445
DO - 10.1093/jnci/djs445
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C2 - 23104324
AN - SCOPUS:84870158807
SN - 0027-8874
VL - 104
SP - 1765
EP - 1769
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 22
ER -
