Mutation in West Nile virus structural protein prM during human infection

Yaniv Lustig; Robert S. Lanciotti; Musa Hindiyeh; Nathan Keller; Ron Milo; Shlomo Mayan; Ella Mendelson

doi:10.3201/eid2209.160132

Mutation in West Nile virus structural protein prM during human infection

Yaniv Lustig
, Robert S. Lanciotti
, Musa Hindiyeh
, Nathan Keller
, Ron Milo
, Shlomo Mayan
, Ella Mendelson

Sheba Medical Center at Tel Hashomer
Centers for Disease Control and Prevention
Tel Aviv University
Ben-Gurion University of the Negev
Barzilai Medical Center

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient’s urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection.

Original language	English
Pages (from-to)	1647-1649
Number of pages	3
Journal	Emerging Infectious Diseases
Volume	22
Issue number	9
DOIs	https://doi.org/10.3201/eid2209.160132
State	Published - Sep 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016, Centers for Disease Control and Prevention (CDC). All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.3201/eid2209.160132

Cite this

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abstract = "A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient{\textquoteright}s urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection.",

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AU - Milo, Ron

AU - Mayan, Shlomo

AU - Mendelson, Ella

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AB - A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient’s urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection.

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Mutation in West Nile virus structural protein prM during human infection

Abstract

Bibliographical note

UN SDGs

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