Mutagenic induction of an ultra-fast water-chain proton wire

Vered Wineman-Fisher; Ron Simkovich; Dan Huppert; Kristina Trujillo; S. James Remington; Yifat Miller

doi:10.1039/c6cp05071a

Mutagenic induction of an ultra-fast water-chain proton wire

Vered Wineman-Fisher, Ron Simkovich, Dan Huppert, Kristina Trujillo, S. James Remington, Yifat Miller

Research output: Contribution to journal › Article › peer-review

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Abstract

Replacement of the hydroxyl group of a hydrophilic sidechain by an H atom in the proton wire of GFP induces formation of a water-chain proton wire. Surprisingly, this "non-native" water chain functions as a proton wire with response times within 10 ps of the wild type protein. This remarkable rate retention is understood as a natural consequence of the well-known Grotthuss mechanism of proton transfer in water.

Original language	English
Pages (from-to)	23089-23095
Number of pages	7
Journal	Physical Chemistry Chemical Physics
Volume	18
Issue number	33
DOIs	https://doi.org/10.1039/c6cp05071a
State	Published - 2016
Externally published	Yes

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Publisher Copyright:
© 2016 the Owner Societies.

Funding

Funders	Funder number
Directorate for Biological Sciences	1021374

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Mutagenic induction of an ultra-fast water-chain proton wire

Abstract

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