TY - JOUR
T1 - Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate
AU - Kahn, Joy
AU - Shwartz, Yulia
AU - Blitz, Einat
AU - Krief, Sharon
AU - Sharir, Amnon
AU - Breitel, Dario A.
AU - Rattenbach, Revital
AU - Relaix, Frederic
AU - Maire, Pascal
AU - Rountree, Ryan B.
AU - Kingsley, David M.
AU - Zelzer, Elazar
PY - 2009/5/19
Y1 - 2009/5/19
N2 - During embryogenesis, organ development is dependent upon maintaining appropriate progenitor cell commitment. Synovial joints develop from a pool of progenitor cells that differentiate into various cell types constituting the mature joint. The involvement of the musculature in joint formation has long been recognized. However, the mechanism by which the musculature regulates joint formation has remained elusive. In this study, we demonstrate, utilizing various murine models devoid of limb musculature or its contraction, that the contracting musculature is fundamental in maintaining joint progenitors committed to their fate, a requirement for correct joint cavitation and morphogenesis. Furthermore, contraction-dependent activation of β-catenin, a key modulator of joint formation, provides a molecular mechanism for this regulation. In conclusion, our findings provide the missing link between progenitor cell fate determination and embryonic movement, two processes shown to be essential for correct organogenesis.
AB - During embryogenesis, organ development is dependent upon maintaining appropriate progenitor cell commitment. Synovial joints develop from a pool of progenitor cells that differentiate into various cell types constituting the mature joint. The involvement of the musculature in joint formation has long been recognized. However, the mechanism by which the musculature regulates joint formation has remained elusive. In this study, we demonstrate, utilizing various murine models devoid of limb musculature or its contraction, that the contracting musculature is fundamental in maintaining joint progenitors committed to their fate, a requirement for correct joint cavitation and morphogenesis. Furthermore, contraction-dependent activation of β-catenin, a key modulator of joint formation, provides a molecular mechanism for this regulation. In conclusion, our findings provide the missing link between progenitor cell fate determination and embryonic movement, two processes shown to be essential for correct organogenesis.
KW - DEVBIO
UR - http://www.scopus.com/inward/record.url?scp=65549130874&partnerID=8YFLogxK
U2 - 10.1016/j.devcel.2009.04.013
DO - 10.1016/j.devcel.2009.04.013
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C2 - 19460349
AN - SCOPUS:65549130874
SN - 1534-5807
VL - 16
SP - 734
EP - 743
JO - Developmental Cell
JF - Developmental Cell
IS - 5
ER -