MULTIVARIATE ANALYSIS OF PROGNOSTIC FACTORS FOR OPERABLE RECTAL CANCER

L. S. Freedman, P. Macaskill, A. N. Smith

Research output: Contribution to journalShort surveypeer-review

151 Scopus citations

Abstract

Previous reports have established that several variables are of prognostic importance in rectal cancer. The information from a Medical Research Council trial in seventeen centres in the United Kingdom was used to assess the simultaneous contribution of several of these factors in a multivariate analysis. In the preoperative assessment mobility of the tumour and the number of quadrants involved were predictive of the likelihood of a curative resection being possible. Among patients who had curative resections, prognosis was influenced by Dukes' classification, height of tumour, histological grade, and venous invasion. A scoring system based on these criteria was constructed and applied to this group of patients. It successfully defined five prognostic groups with 5-year survival rates ranging from 80% to 19%.

Original languageEnglish
Pages (from-to)733-736
Number of pages4
JournalThe Lancet
Volume324
Issue number8405
DOIs
StatePublished - 29 Sep 1984
Externally publishedYes

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