Multisystem Inflammatory Syndrome in Children Associated With Severe Acute Respiratory Syndrome Coronavirus-2 in an 8-Week-Old Infant

Esther Orlanski-Meyer, Dotan Yogev, Adi Auerbach, Orli Megged, Daniel Glikman, Philip J. Hashkes, Maskit Bar-Meir

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We describe an 8-week-old infant with severe gastrointestinal symptoms, significant hypoalbuminemia, and mild carditis following asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infant's symptoms, including their temporal appearance, were consistent with multisystem inflammatory syndrome in children (MIS-C). A unique finding on colonic histology which may shed light on the pathogenesis of MIS-C was identified. The patient improved significantly following several anti-inflammatory treatments. The lag between the presentation of MIS-C and initial SARS-CoV-2 exposure, which may often be asymptomatic, together with the young age of our patient, makes this a challenging diagnosis. Clinicians should be aware of this entity, even in the neonatal and infantile age groups, to facilitate timely identification and treatment.

Original languageEnglish
Pages (from-to)781-784
Number of pages4
JournalJournal of the Pediatric Infectious Diseases Society
Volume9
Issue number6
DOIs
StatePublished - 31 Dec 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s).

Keywords

  • COVID-19
  • Kawasaki
  • MIS-C
  • PIMS

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