TY - JOUR
T1 - Multisystem Inflammatory Syndrome in Children Associated With Severe Acute Respiratory Syndrome Coronavirus-2 in an 8-Week-Old Infant
AU - Orlanski-Meyer, Esther
AU - Yogev, Dotan
AU - Auerbach, Adi
AU - Megged, Orli
AU - Glikman, Daniel
AU - Hashkes, Philip J.
AU - Bar-Meir, Maskit
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - We describe an 8-week-old infant with severe gastrointestinal symptoms, significant hypoalbuminemia, and mild carditis following asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infant's symptoms, including their temporal appearance, were consistent with multisystem inflammatory syndrome in children (MIS-C). A unique finding on colonic histology which may shed light on the pathogenesis of MIS-C was identified. The patient improved significantly following several anti-inflammatory treatments. The lag between the presentation of MIS-C and initial SARS-CoV-2 exposure, which may often be asymptomatic, together with the young age of our patient, makes this a challenging diagnosis. Clinicians should be aware of this entity, even in the neonatal and infantile age groups, to facilitate timely identification and treatment.
AB - We describe an 8-week-old infant with severe gastrointestinal symptoms, significant hypoalbuminemia, and mild carditis following asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infant's symptoms, including their temporal appearance, were consistent with multisystem inflammatory syndrome in children (MIS-C). A unique finding on colonic histology which may shed light on the pathogenesis of MIS-C was identified. The patient improved significantly following several anti-inflammatory treatments. The lag between the presentation of MIS-C and initial SARS-CoV-2 exposure, which may often be asymptomatic, together with the young age of our patient, makes this a challenging diagnosis. Clinicians should be aware of this entity, even in the neonatal and infantile age groups, to facilitate timely identification and treatment.
KW - COVID-19
KW - Kawasaki
KW - MIS-C
KW - PIMS
UR - http://www.scopus.com/inward/record.url?scp=85102091042&partnerID=8YFLogxK
U2 - 10.1093/jpids/piaa137
DO - 10.1093/jpids/piaa137
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C2 - 33175159
AN - SCOPUS:85102091042
SN - 2048-7193
VL - 9
SP - 781
EP - 784
JO - Journal of the Pediatric Infectious Diseases Society
JF - Journal of the Pediatric Infectious Diseases Society
IS - 6
ER -