Multiscale (nano-to-micro) design of integrated nanobio systems

J. W. Jenkins, M. Hagan, A. Chakraborty, S. Sundaram

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

The design of devices that incorporate both nanoscale and continuum scale physics is challenging due to the nature of simulation techniques required for each scale. This paper presents a hierarchical approach where micro/mesoscopic models of molecular phenomena are coupled to continuum device descriptions. This method is developed and demonstrated with reference to DNA hybridization on a microcantilever platform. A macroscopic (Langmuir) model of DNA hybridization is coupled to a mesoscopic description that captures the effect of critical parameters such as salt concentration and graft density. Bridging of the two models was achieved by way of a stochastic Master Equation which was transformed into a Fokker-Planck equivalent that can then be solved in a PDE framework.

Original languageEnglish
Title of host publication2004 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2004
EditorsM. Laudon, B. Romanowicz
Pages22-25
Number of pages4
StatePublished - 2004
Externally publishedYes
Event2004 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2004 - Boston, MA, United States
Duration: 7 Mar 200411 Mar 2004

Publication series

Name2004 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2004
Volume3

Conference

Conference2004 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2004
Country/TerritoryUnited States
CityBoston, MA
Period7/03/0411/03/04

Keywords

  • DNA hybridization
  • Microfluidics
  • Nanoscale modeling

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