Abstract
Dynamic rearrangements of the actin cytoskeleton, following T-cell antigen receptor (TCR) engagement, provide the structural matrix and flexibility to enable intracellular signal transduction, cellular and subcellular remodeling, and driving effector functions. Recently developed cutting-edge imaging technologies have facilitated the study of TCR signaling and its role in actin-dependent processes. In this review, we describe how TCR signaling cascades induce the activation of actin regulatory proteins and the formation of actin networks, and how actin dynamics is important for T-cell homeostasis, activation, migration, and other effector functions.
| Original language | English |
|---|---|
| Pages (from-to) | 4858-4864 |
| Number of pages | 7 |
| Journal | FEBS Letters |
| Volume | 584 |
| Issue number | 24 |
| DOIs | |
| State | Published - 15 Dec 2010 |
Bibliographical note
Funding Information:M.B.S. thanks the following agencies for their research support: The Israel Science Foundation for Grant Nos. 1659/08 , 971/08 and 1503/08 , the Ministries of Health & Science for Grant Nos. 3-4114 and 3-6540 , the Israel Cancer Association through the Estate of the late Alexander Smidoda, and the Taubenblatt Family Foundation for the Bio-medicine excellence grant.
Funding
M.B.S. thanks the following agencies for their research support: The Israel Science Foundation for Grant Nos. 1659/08 , 971/08 and 1503/08 , the Ministries of Health & Science for Grant Nos. 3-4114 and 3-6540 , the Israel Cancer Association through the Estate of the late Alexander Smidoda, and the Taubenblatt Family Foundation for the Bio-medicine excellence grant.
| Funders | Funder number |
|---|---|
| Ministries of Health & Science | 3-4114, 3-6540 |
| Taubenblatt Family Foundation | |
| Israel Cancer Association | |
| Israel Science Foundation | 1659/08, 971/08, 1503/08 |
Keywords
- Actin polymerization
- Lymphocyte activation
- Signaling complex
- TCR
- WASp