@article{e39b7c225ff942b99294abf6fcaf1eff,
title = "Multiparameter Monitoring and Analysis of In Vivo Ischemic and Hypoxic Heart",
abstract = "We describe a unique in vivo technique which addresses the multifactorial function of the heart, i.e., simultaneous measurement of myocardial ion transport (two mini-electrode systems to measure K+cand Ca2+c), energy metabolism (NADH fluorescence to measure NADH redox state), and coronary flow (laser-Doppler perfusion) using a multiprobe assembly (MPA) which contains transducers for all measurements. The MPA (which is 6 mm in diameter) was applied to the external surface of the heart in an open chest dog model. To test MPA function, myocardial ischemia was produced by application of a balloon occluder to the left anterior descending coronary (LAD) artery, and hypoxia was produced by changing the inspired O2-N2ratio until the Pao2was 20-30 torr. The MPA simultaneously monitored changes in ion flux, heart metabolism, and tissue perfusion during pathophysiological intervention.",
keywords = "NADH, coronary flow, hypoxia, ion flux, ischemia, redox state, tissue perfusion",
author = "Mary Osbakken and Avraham Mayevsky and Mary Osbakken",
year = "1996",
month = mar,
doi = "10.1515/jbcpp.1996.7.2.97",
language = "אנגלית",
volume = "7",
pages = "97--114",
journal = "Journal of Basic and Clinical Physiology and Pharmacology",
issn = "0792-6855",
publisher = "Walter de Gruyter GmbH",
number = "2",
}