Multifunctional theranostic gold nanoparticles for targeted CT imaging and photothermal therapy

Taeyjuana Curry, Raoul Kopelman, Malka Shilo, Rachela Popovtzer

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

Gold nanoparticles have emerged as some of the most extensively utilized nanoplatforms for the diagnosis, imaging, monitoring and treatment of malignant diseases. In particular, in computed tomography (CT) imaging and in therapy (PTT), the exploitation of the various, advantageous properties of gold nanoparticles have resulted in numerous advances in each of these fields. The purpose of this review is to assess the status of gold-nanoparticle mediated CT and PTT, highlight several promising outcomes and motivate the combination of these two functionalities in the same nanoparticle platform. The given examples of research based advances and the encouraging results of in vitro and in vivo studies provide much excitement and promise for future theranostic (therapy+diagnostic) clinical applications, as well as for image-guided therapy and/or surgery, and their monitoring.

Original languageEnglish
Pages (from-to)53-61
Number of pages9
JournalContrast Media and Molecular Imaging
Volume9
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • Computed tomography (CT)
  • Gold nanoparticles
  • Photothermal therapy (PTT)

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