Multifunctional magnetite and silica-magnetite nanoparticles: Synthesis, surface activation and applications in life sciences

Aránzazu Del Campo, Tapas Sen, Jean Paul Lellouche, Ian J. Bruce

Research output: Contribution to journalArticlepeer-review

195 Scopus citations

Abstract

A method for the introduction of amine groups onto the surface of magnetite and silica-coated magnetite nanoparticles has been established based on the condensation of aminopropyltriethoxysilane. Amine-modified particles were grafted with an oligonucleotide and used in the capture of a complimentary sequence. The particles' efficiency at capture was observed to correlate directly with amine group surface density.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalJournal of Magnetism and Magnetic Materials
Volume293
Issue number1
DOIs
StatePublished - May 2005

Bibliographical note

Funding Information:
The authors thank the European Union and FP5 (CHEMAG Project, G5RD-CT-2001-00534) for financial support, Dr. Guidi for the SEM and TEM images and E. Borioni for his help in the experimental work.

Keywords

  • Alkoxysilanes
  • DNA immobilisation
  • Silica-magnetite nanocomposites
  • Surface modification

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