Multicolor spectral karyotyping of human chromosomes

E. Schröck, S. Du Manoir, T. Veldman, B. Schoell, J. Wienberg, M. A. Ferguson-Smith, Y. Ning, D. H. Ledbetter, I. Bar-Am, D. Soenksen, Y. Garini, T. Ried

Research output: Contribution to journalArticlepeer-review

1480 Scopus citations


The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance. Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization. By means of computer separation (classification) of spectra, spectrally overlapping chromosome-specific DNA probes could be resolved, and all human chromosomes were simultaneously identified.

Original languageEnglish
Pages (from-to)494-497
Number of pages4
Issue number5274
StatePublished - 26 Jul 1996
Externally publishedYes


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