Mucoactive drug delivery

Israel Amirav, Michael T. Newhouse

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Respiratory-tract secretions consisting of mucus, surfactant, and periciliary fluid are vital components of respiratory defenses since they trap, absorb, dilute, and, by virtue of their contained lysozyme, antibodies, etc., assist in destroying noxious biological and nonbiological invaders. Acute and chronic airway injury results in inflammatory changes, which are usually associated with hypersecretion from goblet cells and mucous glands. The resulting secretions can also be physically abnormal, particularly when they become infected, and this can lead to mucus inspissation, postobstructive atelectasis, and pneumonitis. A vicious circle leading to airway and parenchymal injury and/or destruction with bronchiectasis and pulmonary fibrosis may result and can lead to severe pulmonary dysfunction and death unless the excessive and/or abnormal secretions are eliminated.

Original languageEnglish
Title of host publicationTherapy for Mucus-Clearance Disorders
PublisherCRC Press
Pages147-173
Number of pages27
ISBN (Electronic)9781420030457
ISBN (Print)0824707168, 9780824707163
StatePublished - 1 Jan 2004
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2004 by Marcel Dekker, Inc. All Rights Reserved.

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