mTORC2 Caught in a SINful Akt

Pazit Polak; Michael N. Hall

doi:10.1016/j.devcel.2006.09.005

mTORC2 Caught in a SINful Akt

Pazit Polak
, Michael N. Hall

University of Basel

Research output: Contribution to journal › Short survey › peer-review

46 Scopus citations

Abstract

The target of rapamycin (TOR), a central controller of cell growth, is found in two distinct, highly conserved multiprotein complexes. Three recent papers in Cell (Jacinto et al., 2006), Developmental Cell (Shiota et al., 2006; this issue), and Current Biology (Frias et al., 2006) shed light on mTOR complex 2 (mTORC2) composition and in vivo function. An important new finding is that mTORC2 determines Akt/PKB substrate specificity rather than absolute activity.

Original language	English
Pages (from-to)	433-434
Number of pages	2
Journal	Developmental Cell
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2006.09.005
State	Published - Oct 2006
Externally published	Yes

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10.1016/j.devcel.2006.09.005

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title = "mTORC2 Caught in a SINful Akt",

abstract = "The target of rapamycin (TOR), a central controller of cell growth, is found in two distinct, highly conserved multiprotein complexes. Three recent papers in Cell (Jacinto et al., 2006), Developmental Cell (Shiota et al., 2006; this issue), and Current Biology (Frias et al., 2006) shed light on mTOR complex 2 (mTORC2) composition and in vivo function. An important new finding is that mTORC2 determines Akt/PKB substrate specificity rather than absolute activity.",

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mTORC2 Caught in a SINful Akt

Abstract

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