mTORC2 Caught in a SINful Akt

Pazit Polak, Michael N. Hall

Research output: Contribution to journalShort surveypeer-review

45 Scopus citations


The target of rapamycin (TOR), a central controller of cell growth, is found in two distinct, highly conserved multiprotein complexes. Three recent papers in Cell (Jacinto et al., 2006), Developmental Cell (Shiota et al., 2006; this issue), and Current Biology (Frias et al., 2006) shed light on mTOR complex 2 (mTORC2) composition and in vivo function. An important new finding is that mTORC2 determines Akt/PKB substrate specificity rather than absolute activity.

Original languageEnglish
Pages (from-to)433-434
Number of pages2
JournalDevelopmental Cell
Issue number4
StatePublished - Oct 2006
Externally publishedYes


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