mTOR and the control of whole body metabolism

Pazit Polak, Michael N. Hall

Research output: Contribution to journalReview articlepeer-review

256 Scopus citations

Abstract

Mammalian Target of Rapamycin (mTOR) is a highly conserved protein kinase that functions as part of two distinct multiprotein complexes to regulate growth and metabolism. This review describes the most important recent advances in the mTOR signaling field. In addition, we provide an overview on the functions of mTOR in different organs, with a special focus on the role of mTOR in whole body energy metabolism.

Original languageEnglish
Pages (from-to)209-218
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume21
Issue number2
DOIs
StatePublished - Apr 2009
Externally publishedYes

Bibliographical note

Funding Information:
We apologize to colleagues whose work we could not describe owing to space limitations. MNH acknowledges support from the Swiss National Science Foundation and the Canton of Basel.

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