mRNPs meet stress granules

Jonathan Sheinberger, Yaron Shav-Tal

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Stress granules are cytoplasmic structures that form in response to a variety of cellular stresses. They contain mRNAs and many proteins including numerous types of RNA-binding proteins, and have been studied in connection to major cellular events such as protein synthesis as well as disease. Despite the well-known fact that stress granules encapsulate mRNPs (mRNA–protein complexes), much of the research has naturally focused on the protein components of stress granules. The specific details of mRNP entry into and exit from stress granules and the functional reasons for these dynamics are not fully understood. Here, we review studies that have concentrated on the aspects of mRNP accumulation in stress granules and produced quantitative data concerning mRNP/stress granule interactions.

Original languageEnglish
Pages (from-to)2534-2542
Number of pages9
JournalFEBS Letters
Issue number17
StatePublished - Sep 2017

Bibliographical note

Funding Information:
The work in the Shav-Tal laboratory is supported by the Israel Science Foundation (ISF) and the U.S.-Israel Binational Science Foundation (BSF).

Publisher Copyright:
© 2017 Federation of European Biochemical Societies


  • mRNA dynamics
  • stress granules
  • translation


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