Mother-Infant Interactions in Rats Lacking CCKA Receptors

Yael Lavi-Avnon, Oz Malkesman, Itay Hurwitz, Aron Weller

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Mediation of mother-infant interactions by the brain-gut peptide cholecystokinin (CCK) was examined by observing behavior of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which lack functional CCKA receptors because of a genetic abnormality. OLETF (n = 10) and control (Long-Evans Tokushima Otsuka [LETO] n = 10) dams interacted with 1 pup of each line on Postpartum Days 6-9. OLETF pups received more body and anogenital licking and emitted substantially more ultrasonic vocalizations than LETO pups. OLETF dams carried pups less frequently and showed a nursing position more frequently than LETO dams. No significant Pup x Dam Line interactions or line differences in dams' activity were detected. The results provide convergent validity to previous pharmacological studies implicating CCK mediation of both infant and maternal behavior.

Original languageEnglish
Pages (from-to)282-289
Number of pages8
JournalBehavioral Neuroscience
Issue number2
StatePublished - Apr 2004


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