Mother-Infant Interactions in Rats Lacking CCKA Receptors

Yael Lavi-Avnon; Oz Malkesman; Itay Hurwitz; Aron Weller

doi:10.1037/0735-7044.118.2.282

Mother-Infant Interactions in Rats Lacking CCK_A Receptors

Yael Lavi-Avnon, Oz Malkesman, Itay Hurwitz, Aron Weller

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Mediation of mother-infant interactions by the brain-gut peptide cholecystokinin (CCK) was examined by observing behavior of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which lack functional CCK_A receptors because of a genetic abnormality. OLETF (n = 10) and control (Long-Evans Tokushima Otsuka [LETO] n = 10) dams interacted with 1 pup of each line on Postpartum Days 6-9. OLETF pups received more body and anogenital licking and emitted substantially more ultrasonic vocalizations than LETO pups. OLETF dams carried pups less frequently and showed a nursing position more frequently than LETO dams. No significant Pup x Dam Line interactions or line differences in dams' activity were detected. The results provide convergent validity to previous pharmacological studies implicating CCK mediation of both infant and maternal behavior.

Original language	English
Pages (from-to)	282-289
Number of pages	8
Journal	Behavioral Neuroscience
Volume	118
Issue number	2
DOIs	https://doi.org/10.1037/0735-7044.118.2.282
State	Published - Apr 2004

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Mother-Infant Interactions in Rats Lacking CCK_A Receptors

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