More realistic face model surface improves relevance of pediatric in-vitro aerosol studies

Israel Amirav, Asaf Halamish, Miguel Gorenberg, Hamza Omar, Michael T. Newhouse

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Various hard face models are commonly used to evaluate the efficiency of aerosol face masks. Softer more realistic "face" surface materials, like skin, deform upon mask application and should provide more relevant in-vitro tests. Studies that simultaneously take into consideration many of the factors characteristic of the in vivo face are lacking. These include airways, various application forces, comparison of various devices, comparison with a hard-surface model and use of a more representative model face based on large numbers of actual faces. Aim: To compare mask to "face" seal and aerosol delivery of two pediatric masks using a soft vs. a hard, appropriately representative, pediatric face model under various applied forces. Methods: Two identical face models and upper airways replicas were constructed, the only difference being the suppleness and compressibility of the surface layer of the "face." Integrity of the seal and aerosol delivery of two different masks [AeroChamber (AC) and SootherMask (SM)] were compared using a breath simulator, filter collection and realistic applied forces. Results: The soft "face" significantly increased the delivery efficiency and the sealing characteristics of both masks. Aerosol delivery with the soft "face" was significantly greater for the SM compared to the AC (p< 0.01). No statistically significant difference between the two masks was observed with the hard "face." Conclusions: The material and pliability of the model "face" surface has a significant influence on both the seal and delivery efficiency of face masks. This finding should be taken into account during in-vitro aerosol studies.

Original languageEnglish
Article numbere0128538
JournalPLoS ONE
Issue number6
StatePublished - 19 Jun 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Amirav et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Dive into the research topics of 'More realistic face model surface improves relevance of pediatric in-vitro aerosol studies'. Together they form a unique fingerprint.

Cite this