TY - JOUR
T1 - Monoamines, BDNF, dehydroepiandrosterone, DHEA-Sulfate, and childhood depression - An animal model study
AU - Malkesman, O.
AU - Asaf, Telad
AU - Shbiro, L.
AU - Goldstein, A.
AU - Maayan, R.
AU - Weizman, A.
AU - Kinor, N.
AU - Okun, E.
AU - Sredni, B.
AU - Yadid, G.
AU - Weller, A.
PY - 2009
Y1 - 2009
N2 - Basal levels of monoamines and DHEA in four main limbic brain regions were measured in prepubertal Wistar Kyoto (WKY) rats (a putative animal model of childhood depression). Basal levels of "Brain-Derived Neurotrophic Factor (BDNF)" were also determined in two regions in the hippocampus, compared with Wistar strain controls. In the second phase, we examined the responsiveness of prepubertal WKY rats to different types of chronic antidepressant treatments: Fluoxetine, Desipramine, and dehydroepiandrosterone sulfate (DHEAS). WKY prepubertal rats exhibited different monoamine levels in the limbic system, reduced DHEA levels in the VTA and lower levels of BDNF in the hippocampus CA3 region compared to controls. In prepubertal WKY rats, only treatment with DHEAS produced a statistically significant decrease in immobility, compared to saline-administered controls in the forced swim test. Wistar controls were not affected by any antidepressant. The results imply that DHEA(S) and BDNF may be involved in the pathophysiology and pharmacotherapy of childhood depression.
AB - Basal levels of monoamines and DHEA in four main limbic brain regions were measured in prepubertal Wistar Kyoto (WKY) rats (a putative animal model of childhood depression). Basal levels of "Brain-Derived Neurotrophic Factor (BDNF)" were also determined in two regions in the hippocampus, compared with Wistar strain controls. In the second phase, we examined the responsiveness of prepubertal WKY rats to different types of chronic antidepressant treatments: Fluoxetine, Desipramine, and dehydroepiandrosterone sulfate (DHEAS). WKY prepubertal rats exhibited different monoamine levels in the limbic system, reduced DHEA levels in the VTA and lower levels of BDNF in the hippocampus CA3 region compared to controls. In prepubertal WKY rats, only treatment with DHEAS produced a statistically significant decrease in immobility, compared to saline-administered controls in the forced swim test. Wistar controls were not affected by any antidepressant. The results imply that DHEA(S) and BDNF may be involved in the pathophysiology and pharmacotherapy of childhood depression.
UR - http://www.scopus.com/inward/record.url?scp=70449709180&partnerID=8YFLogxK
U2 - 10.1155/2009/405107
DO - 10.1155/2009/405107
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C2 - 21152205
SN - 1687-6334
VL - 2009
JO - Advances in Pharmacological Sciences
JF - Advances in Pharmacological Sciences
M1 - 405107
ER -