Monitoring of circadian rhythms of heart rate, locomotor activity, and temperature for diagnosis and evaluation of response to treatment in an animal model of depression

Alexander Friedman, Alena Shaldubina, Yakov Flaumenhaft, Abraham Weizman, Gal Yadid

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Depressive disorders affect approximately 5% of the population in developed countries each year. Current antidepressant treatment usually requires several weeks to obtain response or remission and is only effective in about half of depressed patients. Objective diagnostic tools and detection of symptom relief by physiological biomarkers may assist in the clinical decision-making process regarding the selection, replacing, and augmenting of antidepressants. Furthermore, such biomarkers may enable early prediction of the appropriateness of a specific antidepressant for a particular patient. Here, we examined a new non-invasive method for objective diagnosis of depressive-like behavior and for the purpose of predicting antidepressant (paroxetine and desipramine) treatment effectiveness. This method employed a genetic rat model of depression and mathematical analysis of physiological parameters, of circadian rhythms of heart rate, locomotor activity, and temperature for diagnosis and evaluation of response to treatment in an animal model of depression. By utilizing this method, we were able to discern, in a rat model, between depressive and non-depressive individuals and to predict beneficial response to the antidepressants.Mathematical analysis of physiological parameters such as heart rate, locomotor activity, and temperature circadian rhythms can be used for objective diagnosis of depressive-like behavior and for early prediction of response to antidepressant treatment.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalJournal of Molecular Neuroscience
Volume43
Issue number3
DOIs
StatePublished - Mar 2011

Bibliographical note

Funding Information:
Acknowledgments The authors thank E. Nahshoni for critically proofreading the manuscript. AF was supported by a President’s Fellowship, Bar-Ilan University. The research reported in this article was completed as part of AF’s Ph.D. dissertation.

Funding

Acknowledgments The authors thank E. Nahshoni for critically proofreading the manuscript. AF was supported by a President’s Fellowship, Bar-Ilan University. The research reported in this article was completed as part of AF’s Ph.D. dissertation.

FundersFunder number
Bar-Ilan University

    Keywords

    • Antidepressants
    • Circadian rhythms
    • Depression
    • Early onset
    • Heart rate
    • Locomotor activity
    • Temperature

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