Molecular Weight Changes in Polymer Erosion

Antony D’Emanuele, Jennifer Hill, Janet A. Tamada, Abraham J. Domb, Robert Langer

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


We report a study of the effects of polymer molecular weight on the erosion of polyanhydride copolymer matrices composed of 1,3-bis (p-carboxyphenoxy)-propane (CPP) and sebacic acid (SA) in aqueous solution. The erosion profile characteristically displays an induction period during which the erosion rate is relatively slow. The length of this period depends on the initial molecular weight of the polymer. The induction period may be characterized as a time during which a rapid decrease in polymer molecular weight occurs, the end of this period correlating with the time required for the polymer molecular weight to decrease to below a value of approximately 5000 (MW).

Original languageEnglish
Pages (from-to)1279-1283
Number of pages5
JournalPharmaceutical Research
Issue number10
StatePublished - Oct 1992
Externally publishedYes


  • drug delivery system
  • erodible polymers
  • induction period
  • molecular weight
  • polyanhydrides


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