TY - JOUR
T1 - Molecular mechanisms of gossypol action on sperm motility
AU - Breitbart, Haim
AU - Mayevsky, Abraham
AU - Nass-Arden, Lea
PY - 1989
Y1 - 1989
N2 - 1. 1. Gossypol acetic acid inhibits collective motility of ejaculated ram spermatoza. 2. 2. Oxygen consumption was stimulated at low gossypol concentrations and inhibited as the concentrations are increased. 3. 3. Gossypol inhibits respiration of permeabilized spermatozoa supported by durohydroquinome, which indicates a direct inhibition of mitochondrial electron transport chain. 4. 4. The rapid reduction of mitochondrial dependent motility, high uncoupling effect and almost complete inhibition of mitochondrial calcium accumulation, indicate that gossypol inhibits motility in a mechanism by which mitochondrial uncoupling is involved.
AB - 1. 1. Gossypol acetic acid inhibits collective motility of ejaculated ram spermatoza. 2. 2. Oxygen consumption was stimulated at low gossypol concentrations and inhibited as the concentrations are increased. 3. 3. Gossypol inhibits respiration of permeabilized spermatozoa supported by durohydroquinome, which indicates a direct inhibition of mitochondrial electron transport chain. 4. 4. The rapid reduction of mitochondrial dependent motility, high uncoupling effect and almost complete inhibition of mitochondrial calcium accumulation, indicate that gossypol inhibits motility in a mechanism by which mitochondrial uncoupling is involved.
UR - http://www.scopus.com/inward/record.url?scp=0024442747&partnerID=8YFLogxK
U2 - 10.1016/0020-711X(89)90049-9
DO - 10.1016/0020-711X(89)90049-9
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C2 - 2583345
AN - SCOPUS:0024442747
SN - 1357-2725
VL - 21
SP - 1097
EP - 1102
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 10
ER -