Molecular mechanisms of gossypol action on sperm motility

Haim Breitbart, Abraham Mayevsky, Lea Nass-Arden

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


1. 1. Gossypol acetic acid inhibits collective motility of ejaculated ram spermatoza. 2. 2. Oxygen consumption was stimulated at low gossypol concentrations and inhibited as the concentrations are increased. 3. 3. Gossypol inhibits respiration of permeabilized spermatozoa supported by durohydroquinome, which indicates a direct inhibition of mitochondrial electron transport chain. 4. 4. The rapid reduction of mitochondrial dependent motility, high uncoupling effect and almost complete inhibition of mitochondrial calcium accumulation, indicate that gossypol inhibits motility in a mechanism by which mitochondrial uncoupling is involved.

Original languageEnglish
Pages (from-to)1097-1102
Number of pages6
JournalInternational Journal of Biochemistry
Issue number10
StatePublished - 1989


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