Molecular functions of NEDD4 E3 ubiquitin ligases in cancer

Xiao Zou, Gal Levy-Cohen, Michael Blank

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations

Abstract

The initiation, progression and cure of cancer rely heavily on altered gene expression and posttranslational functions. Protein ubiquitination is a major mechanism for posttranslational reorganization of the genome. This evolutionary conserved cascade, through regulation of protein stability, distribution, and function, governs nearly every biological process in the cell. E3 ubiquitin ligases are pivotal components of the ubiquitination pathway. Genetic alterations, abnormal expression, and dysfunctions of E3s have been implicated in the pathogenesis of a wide spectrum of human malignancies. In this review, we summarize and discuss recent discoveries on the roles of NEDD4 E3s in cancer. Over the past decade, members of this family have increasingly surfaced as fundamental components and critical regulators of molecular pathways central to the pathogenesis and cure of the disease.

Original languageEnglish
Pages (from-to)91-106
Number of pages16
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1856
Issue number1
Early online date24 Jun 2015
DOIs
StatePublished - 1 Aug 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V..

Funding

This work was supported by Marie-Curie CIG grant (# 612816 ), Emanuel Kirshner Foundation (# 203287 ) grant, and Morris Khan foundation award to MB. We also thank Harry B. Helmsley Charitable Trust for providing support to our laboratory in the frame of the Faculty Cancer Research Project.

FundersFunder number
Emanuel Kirshner Foundation203287
Marie-Curie CIG612816
Morris Khan foundation

    Keywords

    • Carcinogenesis
    • Metastases
    • NEDD4 E3 ubiquitin ligases
    • Protein ubiquitination
    • Ubiquitin

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