Molecular basis of endothelial dysfunction in sepsis

Kirsten Peters, Ronald E. Unger, Joachim Brunner, C. James Kirkpatrick

Research output: Contribution to journalReview articlepeer-review

236 Scopus citations

Abstract

Sepsis is one of the major causes of mortality in critically ill patients and develops as a result of the host response to infection. A complex network of events is set into motion in the body by the infection and results in the pathogenesis of sepsis. This review article focuses on the molecular mechanisms and components involved in the pathogenesis of sepsis with a major emphasis on the endothelium. This includes sepsis-inducing bacterial components (e.g. endotoxins), cellular targets of these molecules and their responses, host reactions, intracellular and cytokine networks, individual susceptibility and new therapeutic targets in sepsis treatment.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalCardiovascular Research
Volume60
Issue number1
DOIs
StatePublished - 15 Oct 2003
Externally publishedYes

Keywords

  • Cytokines
  • Endothelial function
  • Endotoxins
  • Infection/inflammation
  • Sepsis

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