Modulation of the dose-dependent effects of atropine by low-dose pyridostigmine: Quantification by spectral analysis of heart rate fluctuations in healthy human beings

Shai Izraeli; Menachem Alcalay; Yoav Benjamini; Ruth Wallach-Kapon; Zelig Tochner; Solange Akselrod

doi:10.1016/0091-3057(91)90136-p

Modulation of the dose-dependent effects of atropine by low-dose pyridostigmine: Quantification by spectral analysis of heart rate fluctuations in healthy human beings

Shai Izraeli, Menachem Alcalay, Yoav Benjamini, Ruth Wallach-Kapon, Zelig Tochner, Solange Akselrod

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The interaction between a low-dose cholinesterase inhibitor, pyridostigmine (PYR), and atropine was investigated by spectral analysis of heart rate fluctuations in eight healthy humans. Each subject was given increasing boluses of IV atropine during treatment with PYR (30 mg·3/day) or placebo. PYR attenuated the bimodal dose-dependent changes in the respiratory peak (which represents the parasympathetic control) in response to atropine. We suggest that spectral analysis can be used for quantifying the complex dose-dependent cholinergic agonist-antagonist interactions, and may help to disclose an asymptomatic low-dose intoxication with acetylcholinesterase inhibitors.

Original language	English
Pages (from-to)	613-617
Number of pages	5
Journal	Pharmacology Biochemistry and Behavior
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(91)90136-p
State	Published - Jul 1991
Externally published	Yes

Keywords

Anticholinesterase
Atropine
Humans
Pyridostigmine
Spectral analysis of heart rate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0091-3057(91)90136-p

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title = "Modulation of the dose-dependent effects of atropine by low-dose pyridostigmine: Quantification by spectral analysis of heart rate fluctuations in healthy human beings",

abstract = "The interaction between a low-dose cholinesterase inhibitor, pyridostigmine (PYR), and atropine was investigated by spectral analysis of heart rate fluctuations in eight healthy humans. Each subject was given increasing boluses of IV atropine during treatment with PYR (30 mg·3/day) or placebo. PYR attenuated the bimodal dose-dependent changes in the respiratory peak (which represents the parasympathetic control) in response to atropine. We suggest that spectral analysis can be used for quantifying the complex dose-dependent cholinergic agonist-antagonist interactions, and may help to disclose an asymptomatic low-dose intoxication with acetylcholinesterase inhibitors.",

keywords = "Anticholinesterase, Atropine, Humans, Pyridostigmine, Spectral analysis of heart rate",

author = "Shai Izraeli and Menachem Alcalay and Yoav Benjamini and Ruth Wallach-Kapon and Zelig Tochner and Solange Akselrod",

year = "1991",

month = jul,

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language = "אנגלית",

volume = "39",

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journal = "Pharmacology Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Inc.",

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}

Izraeli, S, Alcalay, M, Benjamini, Y, Wallach-Kapon, R, Tochner, Z & Akselrod, S 1991, 'Modulation of the dose-dependent effects of atropine by low-dose pyridostigmine: Quantification by spectral analysis of heart rate fluctuations in healthy human beings', Pharmacology Biochemistry and Behavior, vol. 39, no. 3, pp. 613-617. https://doi.org/10.1016/0091-3057(91)90136-p

Modulation of the dose-dependent effects of atropine by low-dose pyridostigmine: Quantification by spectral analysis of heart rate fluctuations in healthy human beings. / Izraeli, Shai; Alcalay, Menachem; Benjamini, Yoav et al.
In: Pharmacology Biochemistry and Behavior, Vol. 39, No. 3, 07.1991, p. 613-617.

Research output: Contribution to journal › Article › peer-review

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T1 - Modulation of the dose-dependent effects of atropine by low-dose pyridostigmine

T2 - Quantification by spectral analysis of heart rate fluctuations in healthy human beings

AU - Izraeli, Shai

AU - Alcalay, Menachem

AU - Benjamini, Yoav

AU - Wallach-Kapon, Ruth

AU - Tochner, Zelig

AU - Akselrod, Solange

PY - 1991/7

Y1 - 1991/7

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AB - The interaction between a low-dose cholinesterase inhibitor, pyridostigmine (PYR), and atropine was investigated by spectral analysis of heart rate fluctuations in eight healthy humans. Each subject was given increasing boluses of IV atropine during treatment with PYR (30 mg·3/day) or placebo. PYR attenuated the bimodal dose-dependent changes in the respiratory peak (which represents the parasympathetic control) in response to atropine. We suggest that spectral analysis can be used for quantifying the complex dose-dependent cholinergic agonist-antagonist interactions, and may help to disclose an asymptomatic low-dose intoxication with acetylcholinesterase inhibitors.

KW - Anticholinesterase

KW - Atropine

KW - Humans

KW - Pyridostigmine

KW - Spectral analysis of heart rate

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Modulation of the dose-dependent effects of atropine by low-dose pyridostigmine: Quantification by spectral analysis of heart rate fluctuations in healthy human beings

Abstract

Keywords

UN SDGs

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