Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Walter Dunn; Yuri Rassovsky; Jonathan K. Wynn; Allan D. Wu; Marco Iacoboni; Gerhard Hellemann; Michael F. Green

doi:10.1016/j.schres.2016.04.021

Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Walter Dunn
, Yuri Rassovsky
, Jonathan K. Wynn
, Allan D. Wu
, Marco Iacoboni
, Gerhard Hellemann
, Michael F. Green

Department of Psychology

VA Medical Center
University of California at Los Angeles

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.

Original language	English
Pages (from-to)	189-191
Number of pages	3
Journal	Schizophrenia Research
Volume	174
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2016.04.021
State	Published - 1 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016.

Funding

This study was supported by the Veterans Administration (VA) Desert Pacific Veterans Integrated Service Network 22 (VISN 22) Mental Illness Research , Education and Clinical Center (MIRECC) infrastructure and by a NARSAD Independent Investigator Grant (PI: Yuri Rassovsky) from the Brain & Behavior Research Foundation ( 22017 ). This studywas supported by theVeterans Administration (VA)Desert Pacific Veterans Integrated Service Network 22 (VISN 22) Mental Illness Research, Education and Clinical Center (MIRECC) infrastructure and by a NARSAD Independent Investigator Grant (PI: Yuri Rassovsky) from the Brain & Behavior Research Foundation (22017).

Funders	Funder number
Administration
Veterans Administration
U.S. Department of Veterans Affairs
Brain and Behavior Research Foundation	22017
National Alliance for Research on Schizophrenia and Depression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cognition
Mismatch negativity
Schizophrenia
Target engagement
Transcranial direct current stimulation
tDCS

Access to Document

10.1016/j.schres.2016.04.021

Cite this

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Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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