TY - JOUR
T1 - Modulation of heart rate variability by estrogen in young women undergoing induction of ovulation
AU - Weissman, Amir
AU - Lowenstein, Lior
AU - Tal, Joseph
AU - Ohel, Gonen
AU - Calderon, Ilan
AU - Lightman, Abraham
PY - 2009/2
Y1 - 2009/2
N2 - Estrogens are involved in the modulation of the cardiovascular system, yet their effects in young women remains largely unknown. Women who undergo ovulation induction treatments attain extremely high estrogen concentrations during a very short time period. The aim of the present study was to evaluate the effects of an acute increase in estrogens on the autonomic nervous system modulation of heart rate variability (HRV). A total of 27 women undergoing ovulation induction and 14 normally menstruating women were prospectively studied. HRV was assessed during nadir and peak estrogen using time domain and power spectral density analyses. A significant increase in high-frequency spectral power (243 ± 77 vs. 188 ± 73 ms2/Hz, P < 0.01) with a significant decrease in the ratio of low to high-frequency power was observed during estrogen peak in women undergoing induction of ovulation. The acute increase in estrogen in women undergoing ovulation induction was associated with vagal activation and altered sympathovagal balance.
AB - Estrogens are involved in the modulation of the cardiovascular system, yet their effects in young women remains largely unknown. Women who undergo ovulation induction treatments attain extremely high estrogen concentrations during a very short time period. The aim of the present study was to evaluate the effects of an acute increase in estrogens on the autonomic nervous system modulation of heart rate variability (HRV). A total of 27 women undergoing ovulation induction and 14 normally menstruating women were prospectively studied. HRV was assessed during nadir and peak estrogen using time domain and power spectral density analyses. A significant increase in high-frequency spectral power (243 ± 77 vs. 188 ± 73 ms2/Hz, P < 0.01) with a significant decrease in the ratio of low to high-frequency power was observed during estrogen peak in women undergoing induction of ovulation. The acute increase in estrogen in women undergoing ovulation induction was associated with vagal activation and altered sympathovagal balance.
KW - Autonomic nervous system
KW - Estrogen
KW - Heart rate variability
UR - https://www.scopus.com/pages/publications/59249095899
U2 - 10.1007/s00421-008-0914-4
DO - 10.1007/s00421-008-0914-4
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C2 - 18989692
AN - SCOPUS:59249095899
SN - 1439-6319
VL - 105
SP - 381
EP - 386
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 3
ER -
