Modulating behavioral inhibition by tDCS combined with cognitive training

Thomas Ditye, Liron Jacobson, Vincent Walsh, Michal Lavidor

Research output: Contribution to journalArticlepeer-review

187 Scopus citations

Abstract

Cognitive training is an effective tool to improve a variety of cognitive functions, and a small number of studies have now shown that brain stimulation accompanying these training protocols can enhance their effects. In the domain of behavioral inhibition, little is known about how training can affect this skill. As for transcranial direct current stimulation (tDCS), it was previously found that stimulation over the right inferior frontal gyrus (rIFG) facilitates behavioral inhibition performance and modulates its electrophysiological correlates. This study aimed to investigate this behavioral facilitation in the context of a learning paradigm by giving tDCS over rIFG repetitively over four consecutive days of training on a behavioral inhibition task (stop signal task (SST)). Twentytwo participants took part; ten participants were assigned to receive anodal tDCS (1.5 mA, 15 min), 12 were assigned to receive training but not active stimulation. There was a significant effect of training on learning and performance in the SST, and the integration of the training and rIFG-tDCS produced a more linear learning slope. Better performance was also found in the active stimulation group. Our findings show that tDCS-combined cognitive training is an effective tool for improving the ability to inhibit responses. The current study could constitute a step toward the use of tDCS and cognitive training as a therapeutic tool for cognitive control impairments in conditions such as attention-deficit hyperactivity disorder (ADHD) or schizophrenia.

Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalExperimental Brain Research
Volume219
Issue number3
DOIs
StatePublished - Jun 2012

Bibliographical note

Funding Information:
Acknowledgments TD, VW, and ML are members of the Marie Curie ITN-LAN network funded by the EC. LJ and ML are supported by an ERC start-up grant awarded to ML. VW is supported a Royal Society Industry Fellow.

Funding

Acknowledgments TD, VW, and ML are members of the Marie Curie ITN-LAN network funded by the EC. LJ and ML are supported by an ERC start-up grant awarded to ML. VW is supported a Royal Society Industry Fellow.

FundersFunder number
Medical Research CouncilG0700929
European Commission
European Research Council

    Keywords

    • Behavioral inhibition
    • Cognitive training
    • RIFG
    • Stop signal task

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