Modification of the hypothermic circadian cycles induced by DSIP and melatonin in pinealectomized and hypophysectomized rats

Shlomo Yehuda, David I. Mostofsky

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Both melatonin and DSIP (a nine amino acid peptide) effects have been previously shown to be (a) circadian rhythm related and (b) involved in inducing hypothermic effects in rats. In this study we report the hypothermia effects by each of these drugs alone and in combination when studied in normal (unoperated), pinealectomized, and hypophysectomized rats at various time points of the corresponding circadian cycle. A clear differential effect of drugs × time × preparation was found. While both DSIP and melatonin hypothermic effects were both circadian cycle dependent in intact rats the rhythmicity of melatonin hypothermic effect in pinealectomized rats, and DSIP hypothermic effect in hypophysectomized rats was missing. Although several hypotheses have been offered to account for the physiological mechanism(s) that govern the effects of the drugs, it is not yet possible to reliably relate the findings to existing neurochemical theory.

Original languageEnglish
Pages (from-to)495-497
Number of pages3
JournalPeptides
Volume5
Issue number3
DOIs
StatePublished - 1984

Bibliographical note

Funding Information:
This study was supported in part by the Bar-Ilan Research Authority and by a grant from the Spiegel Foundation.

Keywords

  • Circadian rhythms
  • DSIP
  • Melatonin
  • Pineal
  • Pituitary gland

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