Modification of the computational procedure in Parker and Bregman's method of calculating sample size from matched case-control studies with a dichotomous exposure

Ilya Novikov, Bernice Oberman, Laurence Freedman

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Several authors have addressed the problem of calculating sample size for a matched case-control study with a dichotomous exposure. The approach of Parker and Bregman (1986, Biometrics42, 919-926) is, in our view, one of the most satisfactory, since it requires specification of quantities that are often easily available to the investigator. However, its recommended implementation involves a computational approximation. We show here that the approximation performs poorly in extreme situations and can be easily replaced with a more exact calculation.

Original languageEnglish
Pages (from-to)1123-1126
Number of pages4
JournalBiometrics
Volume61
Issue number4
DOIs
StatePublished - Dec 2005

Keywords

  • Case-control study
  • Dichotomous exposure
  • Matched design
  • Reye's syndrome
  • Sample size calculation

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