Modification of d-amphetamine- or chlorpromazine-induced hypothermia by β-endorphin, MIF-I, and α-MSH: Mediation by the dopaminergic system

Shlomo Yehuda, Ralph L. Carasso

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The effects of β-endorphin, MIF-I, and α-MSH on d-amphetamine- and CPZ-induced hypothermias in rats kept at 4°C were tested in three experimental groups: (a) intact; (b) rats with lesions of the olfactory tubercle; and (c) rats in which the link between the DA mesolimbic pathway and the striatum was disconnected. All drugs tested alone (except MIF-I) caused significant hypothermia. Pretreatment with CPZ, MIF-I, and α-MSH potentiated d-amphetamine-induced hypothermia in intact rats. Pretreatment with α-MSH potentiated CPZ-induced hypothermia. β-Endorphin partially blocked d-amphetamine-induced hypothermia, but did not interact with CPZ, MIF-I, or α-MSH. All potentiations were either reduced or disappeared in the incisioned rats. CPZ and α-MSH caused hypothermia in olfactory tubercle-lesioned rats. The results indicate that: (a) the DA mesolimbic pathway is involved in the hypothermic response of all drugs tested; (b) an intact feedback loop is required for the potentiation of the hypothermic response of CPZ on d-amphetamine, MIF-I on d-amphetamine, and α-MSH on d-amphetamine and CPZ; (c) β-endorphin acts as a partial blocker of d-amphetamine; MIF-I is a weak potentiator of d-amphetamine. α-MSH acts as a negative modulator of the DA system, most probably in the striatum.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalPeptides
Volume3
Issue number2
DOIs
StatePublished - 1982

Keywords

  • CPZ
  • Drug interaction
  • Hypothermia
  • MIF-I
  • Striatum Olfactory tubercle
  • d-Amphetamine
  • α-MSH
  • β-Endorphin

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