Abstract
In recent years it has emerged that acetylation, and especially the activity of certain deacetylases, regulates lifespan in model organisms. Among the three classes of deacetylases, the role of class III, sirtuins NAD+-dependent deacetylases, in regulating aging is the best studied. Sirtuins are conserved from bacteria to human and overexpression of sirtuins in yeast, nematodes and flies extends their lifespan, implying a conserved fundamental mechanism by which sirtuins regulate aging. In this review we will focus on the role of deacetylases, especially sirtuins, in regulating longevity and will describe and discuss their role in regulating lifespan from yeast to human.
| Original language | English |
|---|---|
| Pages (from-to) | 265-271 |
| Number of pages | 7 |
| Journal | Drug Discovery Today: Disease Models |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2005 |
Bibliographical note
Funding Information:We thank members of the Cohen's lab for editorial comments and apologize for those whose work was not cited owing to space limitations. The work in the Cohen's lab was supported by the Koret, Alon and the German–Israeli foundations.
Funding
We thank members of the Cohen's lab for editorial comments and apologize for those whose work was not cited owing to space limitations. The work in the Cohen's lab was supported by the Koret, Alon and the German–Israeli foundations.
| Funders | Funder number |
|---|---|
| German–Israeli foundations |