Modeling the influence of TH1- and TH2-type cells in autoimmune diseases

Yoram Louzoun; Henri Atlan; Irun R. Cohen

doi:10.1006/jaut.2001.0548

Modeling the influence of TH1- and TH2-type cells in autoimmune diseases

Yoram Louzoun, Henri Atlan, Irun R. Cohen

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A sharp TH1/TH2 dichotomy has often been used to define the effects of cytokines on autoimmune diseases. However contradictory results in recent research indicate that the situation may be more complex. Here, we build a simple mathematical model aimed at settling the contradictions. The model is applied using Ordinary Differential Equations (ODE). We show here that a TH1/TH2 paradigm is only an external view of a complex multivariate system.

Original language	English
Pages (from-to)	311-321
Number of pages	11
Journal	Journal of Autoimmunity
Volume	17
Issue number	4
DOIs	https://doi.org/10.1006/jaut.2001.0548
State	Published - 1 Dec 2001
Externally published	Yes

Keywords

EAE
IDDM
Mathematical models
Network
TH1

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10.1006/jaut.2001.0548

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Modeling the influence of TH1- and TH2-type cells in autoimmune diseases

Abstract

Keywords

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