Modeling the influence of TH1- and TH2-type cells in autoimmune diseases

Yoram Louzoun, Henri Atlan, Irun R. Cohen

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A sharp TH1/TH2 dichotomy has often been used to define the effects of cytokines on autoimmune diseases. However contradictory results in recent research indicate that the situation may be more complex. Here, we build a simple mathematical model aimed at settling the contradictions. The model is applied using Ordinary Differential Equations (ODE). We show here that a TH1/TH2 paradigm is only an external view of a complex multivariate system.

Original languageEnglish
Pages (from-to)311-321
Number of pages11
JournalJournal of Autoimmunity
Issue number4
StatePublished - 1 Dec 2001
Externally publishedYes


  • EAE
  • IDDM
  • Mathematical models
  • Network
  • TH1


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