Model of unequal chromosomal crossing over in DNA sequences

Nikolay V. Dokholyan; Sergey V. Buldyrev; Shlomo Havlin; H. Eugene Stanley

doi:10.1016/S0378-4371(97)00520-7

Model of unequal chromosomal crossing over in DNA sequences

Nikolay V. Dokholyan, Sergey V. Buldyrev, Shlomo Havlin, H. Eugene Stanley

Department of Physics

Boston University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

It is known that some dimeric tandem repeats (DTR) are very abundant in noncoding DNA. We find that certain DTR length distribution functions in noncoding DNA can be fit by a power law function. We analyze a simplified model of unequal chromosomal crossing over and find that it produces a stable power law length distribution function, with the exponent μ = 2. Although the exponent predicted by this model differs from those observed in nature, we argue that the biophysical process underlying this model provides the major contribution to the DTR length distribution function.

Original language	English
Pages (from-to)	594-599
Number of pages	6
Journal	Physica A: Statistical Mechanics and its Applications
Volume	249
Issue number	1-4
DOIs	https://doi.org/10.1016/S0378-4371(97)00520-7
State	Published - 2 Jan 1998

Bibliographical note

Funding Information:
This work is supported by NIH-HGP.

Funding

This work is supported by NIH-HGP.

Funders	Funder number
NIH-HGP

Keywords

DNA
Mutations
Repeats

Access to Document

10.1016/S0378-4371(97)00520-7

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title = "Model of unequal chromosomal crossing over in DNA sequences",

abstract = "It is known that some dimeric tandem repeats (DTR) are very abundant in noncoding DNA. We find that certain DTR length distribution functions in noncoding DNA can be fit by a power law function. We analyze a simplified model of unequal chromosomal crossing over and find that it produces a stable power law length distribution function, with the exponent μ = 2. Although the exponent predicted by this model differs from those observed in nature, we argue that the biophysical process underlying this model provides the major contribution to the DTR length distribution function.",

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AU - Dokholyan, Nikolay V.

AU - Buldyrev, Sergey V.

AU - Havlin, Shlomo

AU - Stanley, H. Eugene

N1 - Funding Information: This work is supported by NIH-HGP.

PY - 1998/1/2

Y1 - 1998/1/2

N2 - It is known that some dimeric tandem repeats (DTR) are very abundant in noncoding DNA. We find that certain DTR length distribution functions in noncoding DNA can be fit by a power law function. We analyze a simplified model of unequal chromosomal crossing over and find that it produces a stable power law length distribution function, with the exponent μ = 2. Although the exponent predicted by this model differs from those observed in nature, we argue that the biophysical process underlying this model provides the major contribution to the DTR length distribution function.

AB - It is known that some dimeric tandem repeats (DTR) are very abundant in noncoding DNA. We find that certain DTR length distribution functions in noncoding DNA can be fit by a power law function. We analyze a simplified model of unequal chromosomal crossing over and find that it produces a stable power law length distribution function, with the exponent μ = 2. Although the exponent predicted by this model differs from those observed in nature, we argue that the biophysical process underlying this model provides the major contribution to the DTR length distribution function.

KW - DNA

KW - Mutations

KW - Repeats

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JO - Physica A: Statistical Mechanics and its Applications

JF - Physica A: Statistical Mechanics and its Applications

IS - 1-4

ER -

Model of unequal chromosomal crossing over in DNA sequences

Abstract

Bibliographical note

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Keywords

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