Model of DNA bending by cooperative binding of proteins

S. M. Rappaport, Y. Rabin

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We present a model of nonspecific cooperative binding of proteins to DNA in which the binding of isolated proteins generates local bends but binding of proteins at neighboring sites on DNA straightens the polymer. We solve the statistical mechanical problem and calculate the effective persistence length, site occupancy, and cooperativity. Cooperativity leads to nonmonotonic variation of the persistence length with protein concentration, and to an unusual shape of the binding isotherm. The results are in qualitative agreement with recent single molecule experiments on nucleoid protein HU-DNA complexes.

Original languageEnglish
Article number038101
JournalPhysical Review Letters
Issue number3
StatePublished - 14 Jul 2008


Dive into the research topics of 'Model of DNA bending by cooperative binding of proteins'. Together they form a unique fingerprint.

Cite this