Mn(III)-Salen Protect Against Different ROS Species Generated by the Aβ16-Cu Complex

Gulshan R. Walke; Dnyanesh S. Ranade; Archika M. Bapat; Rapole Srikanth; Prasad P. Kulkarni

doi:10.1002/slct.201600808

Mn(III)-Salen Protect Against Different ROS Species Generated by the Aβ16-Cu Complex

Gulshan R. Walke, Dnyanesh S. Ranade, Archika M. Bapat, Rapole Srikanth, Prasad P. Kulkarni

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Aβ-Cu complex generates different reactive oxygen species (ROS) which are responsible for oxidative stress in neuronal cells. We studied the effect of Mn(III)-salen on Aβ-Cu catalyzed ROS generation using different assays. Mn(III)-salen reacts with O₂ ^•− generated by Aβ-Cu and delay H₂O₂ production. Mn(III)-salen significantly inhibits the formation of HO^• generated by Aβ-Cu which is further confirmed using mass spectrometry analysis. Our results indicate that H₂O₂ generated by Aβ-Cu activates Mn(III)-salen to oxomanganese which in turn detoxify Aβ-Cu-induced NO production in microglial cells. Overall, Mn(III)-salen complex can efficiently inhibits different ROS generated by Aβ-Cu due to its redox flexibility.

Original language	English
Pages (from-to)	3497-3501
Number of pages	5
Journal	ChemistrySelect
Volume	1
Issue number	13
DOIs	https://doi.org/10.1002/slct.201600808
State	Published - 16 Aug 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Funding

This work was supported by the funds from Department of Science and Technology, India (EMR/2014/001235) and Department Of Biotechnology, India (BT/PR3871/MED/30/830/2012). Authors thank Mr. V. Naik, Proteomics Laboratory, NCCS for the help in mass spectral measurements; and Dr. K. M. Paknikar, Agharkar Research Institute for instrumental facility.

Funders	Funder number
Department Of Biotechnology, India	BT/PR3871/MED/30/830/2012
Department of Science and Technology, Government of Kerala	EMR/2014/001235

Keywords

Alzheimer′s disease
Amyloid beta peptide
Copper
Mn(III)-salen
Oxidative stress

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10.1002/slct.201600808

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title = "Mn(III)-Salen Protect Against Different ROS Species Generated by the Aβ16-Cu Complex",

abstract = "Aβ-Cu complex generates different reactive oxygen species (ROS) which are responsible for oxidative stress in neuronal cells. We studied the effect of Mn(III)-salen on Aβ-Cu catalyzed ROS generation using different assays. Mn(III)-salen reacts with O2 •− generated by Aβ-Cu and delay H2O2 production. Mn(III)-salen significantly inhibits the formation of HO• generated by Aβ-Cu which is further confirmed using mass spectrometry analysis. Our results indicate that H2O2 generated by Aβ-Cu activates Mn(III)-salen to oxomanganese which in turn detoxify Aβ-Cu-induced NO production in microglial cells. Overall, Mn(III)-salen complex can efficiently inhibits different ROS generated by Aβ-Cu due to its redox flexibility.",

keywords = "Alzheimer′s disease, Amyloid beta peptide, Copper, Mn(III)-salen, Oxidative stress",

author = "Walke, {Gulshan R.} and Ranade, {Dnyanesh S.} and Bapat, {Archika M.} and Rapole Srikanth and Kulkarni, {Prasad P.}",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2016",

month = aug,

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doi = "10.1002/slct.201600808",

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T1 - Mn(III)-Salen Protect Against Different ROS Species Generated by the Aβ16-Cu Complex

AU - Walke, Gulshan R.

AU - Ranade, Dnyanesh S.

AU - Bapat, Archika M.

AU - Srikanth, Rapole

AU - Kulkarni, Prasad P.

PY - 2016/8/16

Y1 - 2016/8/16

N2 - Aβ-Cu complex generates different reactive oxygen species (ROS) which are responsible for oxidative stress in neuronal cells. We studied the effect of Mn(III)-salen on Aβ-Cu catalyzed ROS generation using different assays. Mn(III)-salen reacts with O2 •− generated by Aβ-Cu and delay H2O2 production. Mn(III)-salen significantly inhibits the formation of HO• generated by Aβ-Cu which is further confirmed using mass spectrometry analysis. Our results indicate that H2O2 generated by Aβ-Cu activates Mn(III)-salen to oxomanganese which in turn detoxify Aβ-Cu-induced NO production in microglial cells. Overall, Mn(III)-salen complex can efficiently inhibits different ROS generated by Aβ-Cu due to its redox flexibility.

AB - Aβ-Cu complex generates different reactive oxygen species (ROS) which are responsible for oxidative stress in neuronal cells. We studied the effect of Mn(III)-salen on Aβ-Cu catalyzed ROS generation using different assays. Mn(III)-salen reacts with O2 •− generated by Aβ-Cu and delay H2O2 production. Mn(III)-salen significantly inhibits the formation of HO• generated by Aβ-Cu which is further confirmed using mass spectrometry analysis. Our results indicate that H2O2 generated by Aβ-Cu activates Mn(III)-salen to oxomanganese which in turn detoxify Aβ-Cu-induced NO production in microglial cells. Overall, Mn(III)-salen complex can efficiently inhibits different ROS generated by Aβ-Cu due to its redox flexibility.

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KW - Amyloid beta peptide

KW - Copper

KW - Mn(III)-salen

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Mn(III)-Salen Protect Against Different ROS Species Generated by the Aβ16-Cu Complex

Abstract

Bibliographical note

Funding

Keywords

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