TY - JOUR
T1 - Mitochondrial reactive oxygen species at The heart of The matter
T2 - New therapeutic approaches for cardiovascular diseases
AU - Kornfeld, Opher S.
AU - Hwang, Sunhee
AU - Disatnik, Marie Hélène
AU - Chen, Che Hong
AU - Qvit, Nir
AU - Mochly-Rosen, Daria
N1 - Publisher Copyright:
© 2015 American Heart Association, Inc.
PY - 2015/5/22
Y1 - 2015/5/22
N2 - Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into The clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge The traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.
AB - Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into The clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge The traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.
KW - mitochondria
KW - mitochondrial degradation
KW - mitochondrial dynamics
KW - protein kinase C
KW - reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=84942777656&partnerID=8YFLogxK
U2 - 10.1161/CIRCRESAHA.116.305432
DO - 10.1161/CIRCRESAHA.116.305432
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C2 - 25999419
AN - SCOPUS:84942777656
SN - 0009-7330
VL - 116
SP - 1783
EP - 1799
JO - Circulation Research
JF - Circulation Research
IS - 11
ER -
