TY - JOUR
T1 - Mitochondrial function and energy metabolism in cancer cells
T2 - Past overview and future perspectives
AU - Mayevsky, Avraham
PY - 2009/6
Y1 - 2009/6
N2 - The involvements of energy metabolism aspects of mitochondrial dysfunction in cancer development, proliferation and possible therapy, have been investigated since Otto Warburg published his hypothesis. The main published material on cancer cell energy metabolism is overviewed and a new unique in vivo experimental approach that may have significant impact in this important field is suggested. The monitoring system provides real time data, reflecting mitochondrial NADH redox state and microcirculation function. This approach of in vivo monitoring of tissue viability could be used to test the efficacy and side effects of new anticancer drugs in animal models. Also, the same technology may enable differentiation between normal and tumor tissues in experimental animals and maybe also in patients.
AB - The involvements of energy metabolism aspects of mitochondrial dysfunction in cancer development, proliferation and possible therapy, have been investigated since Otto Warburg published his hypothesis. The main published material on cancer cell energy metabolism is overviewed and a new unique in vivo experimental approach that may have significant impact in this important field is suggested. The monitoring system provides real time data, reflecting mitochondrial NADH redox state and microcirculation function. This approach of in vivo monitoring of tissue viability could be used to test the efficacy and side effects of new anticancer drugs in animal models. Also, the same technology may enable differentiation between normal and tumor tissues in experimental animals and maybe also in patients.
KW - Microcirculatory blood flow
KW - Mitochondrial function
KW - NADH redox state
KW - Tumor viability
KW - Warburg hypothesis
UR - http://www.scopus.com/inward/record.url?scp=64549106080&partnerID=8YFLogxK
U2 - 10.1016/j.mito.2009.01.009
DO - 10.1016/j.mito.2009.01.009
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C2 - 19460294
AN - SCOPUS:64549106080
SN - 1567-7249
VL - 9
SP - 165
EP - 179
JO - Mitochondrion
JF - Mitochondrion
IS - 3
ER -
