TY - JOUR
T1 - Miniature electrical stimulator for hemorrhage control,
AU - Mark, Brinton R.
AU - Mandel, Yossi
AU - Dalal, Roopa
AU - Palanker, Daniel
PY - 2014
Y1 - 2014
N2 - Noncompressible hemorrhage is currently the most common cause of preventable death in battlefield and in civilian trauma injuries. Tourniquets, specialized wound dressings, and hemorrhage-inhibiting biomaterials are not sufficiently effective in arrest of noncompressible hemorrhage and often cause collateral tissue damage. An effective, easy-to-use, portable device is needed to reduce blood loss in trauma patients immediately following injury and to maintain hemorrhage control up to several hours-until the injured is evacuated to a medical facility. We developed a miniature electrical stimulator to induce vascular constriction and, thereby, reduce hemorrhage. Vasoconstriction of the rat femoral arteries and veins was studied with pulse durations in the range of 1 $\mu$s to 10 ms and repetition rate of 10 Hz. Pulse amplitude of 20 V, duration of 1 ms, and repetition rate of 10 Hz were found sufficient to induce rapid constriction down to 31 ± 2\% of the initial diameter, which could be maintained throughout a two-hour treatment. Within one minute following treatment termination the artery dilated back to 88 ± 3\% of the initial diameter, providing rapid restoration of blood perfusion. Histology indicated no damage to the vessel wall and endothelium seven days after stimulation. The same treatment reduced the blood loss following complete femoral artery resection by 68 ± 11\%, compared to untreated vessels. Very low power consumption during stimulation (\textless10 mW per 1.6 mm electrode) allows miniaturization of the stimulator for portable battery-powered operation in the field to control the blood loss following vascular trauma.,
AB - Noncompressible hemorrhage is currently the most common cause of preventable death in battlefield and in civilian trauma injuries. Tourniquets, specialized wound dressings, and hemorrhage-inhibiting biomaterials are not sufficiently effective in arrest of noncompressible hemorrhage and often cause collateral tissue damage. An effective, easy-to-use, portable device is needed to reduce blood loss in trauma patients immediately following injury and to maintain hemorrhage control up to several hours-until the injured is evacuated to a medical facility. We developed a miniature electrical stimulator to induce vascular constriction and, thereby, reduce hemorrhage. Vasoconstriction of the rat femoral arteries and veins was studied with pulse durations in the range of 1 $\mu$s to 10 ms and repetition rate of 10 Hz. Pulse amplitude of 20 V, duration of 1 ms, and repetition rate of 10 Hz were found sufficient to induce rapid constriction down to 31 ± 2\% of the initial diameter, which could be maintained throughout a two-hour treatment. Within one minute following treatment termination the artery dilated back to 88 ± 3\% of the initial diameter, providing rapid restoration of blood perfusion. Histology indicated no damage to the vessel wall and endothelium seven days after stimulation. The same treatment reduced the blood loss following complete femoral artery resection by 68 ± 11\%, compared to untreated vessels. Very low power consumption during stimulation (\textless10 mW per 1.6 mm electrode) allows miniaturization of the stimulator for portable battery-powered operation in the field to control the blood loss following vascular trauma.,
UR - http://scholar.google.com/scholar?num=3&hl=en&lr=&q=allintitle%3A%20Miniature%20electrical%20stimulator%20for%20hemorrhage%20control%2C%20author%3AMark%20OR%20author%3ABrinton%20OR%20author%3AYossi%20OR%20author%3AMandel%20OR%20author%3ARoopa%20OR%20author%3ADalal%20OR%20author%3ADaniel%20OR%20author%3APalanker&as_ylo=2014&as_yhi=&btnG=Search&as_vis=0
M3 - Article
VL - 61
SP - 1765
EP - 1771
JO - IEEE Transactions on Biomedical Engineering,
JF - IEEE Transactions on Biomedical Engineering,
IS - 6,
ER -
