Midazolam acts synergistically with methohexitone for induction of anaesthesia

M. Tverskoy, I. Ben-shlomo, J. Ezry, J. Finger, G. Fleyshman

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21 Scopus citations


The induction dose-response of midazolam was compared with the dose-response of its combination with methohexitone sodium and with that of methohexitone alone. Three groups of 60 unpremedicated ASA physical state I or II women undergoing minor gynaecological interventions were studied. The end-point of induction of anaesthesia was inability to open eyes upon command. Dose-response curves were determined for each group with a probit procedure and compared with an isobolographic analysis. Midazolam was found to act in synergism with methohexitone for induction of anaesthesia. Twenty-seven percent ED50 for methohexitone was required in combination with 33% of ED50 for midazolam to achieve the ED50 of the combination. This degree of synergism is in agreement with that described in animal research.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalBritish Journal of Anaesthesia
Issue number1
StatePublished - Jul 1989
Externally publishedYes


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