In the past twenty years, our ability to manipulate and engineer devices at the nano-scale has grown exponentially. As the fabrication of autonomous systems at these scales becomes a reality, the observation of biological structures can help us understand general design principles at the nano-scale. The gliding motility assay is an excellent model system for the observation of collective behavior of coupled motors. Indeed, hundreds of surface-Adhered kinesin motors propel one microtubule filament (Figure 1). Filament motion has been observed using fluorescence microscopy, revealing fluctuations in gliding velocity [3; 4]. We here theoretically characterize the motional diffusion coefficients through the heterogeneity factor proposed by Sekimoto and Tawada , and use a Brownian dynamics simulation of kinesin head diffusion under an anharmonic potential to determine a theoretical value of 0.3 for this heterogeneity factor.
|Journal||EAI International Conference on Bio-inspired Information and Communications Technologies (BICT)|
|State||Published - 2015|
|Event||9th EAI International Conference on Bio-Inspired Information and Communications Technologies, BICT 2015 - New York City, United States|
Duration: 3 Dec 2015 → 5 Dec 2015
Bibliographical notePublisher Copyright:
© 2016 ICST.
- Brownian dynamics
- Motility assay
- Motor protein