Microparticulate polymers and hydrogels for wound healing

R. Ghadi, A. Jain, W. Khan, A. J. Domb

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

29 Scopus citations

Abstract

Traditional treatment of open wounds engaged bandages such as gauze of cotton, wool or lint with the primary function to keep the wound dry. Findings now show that proper natural or synthetic biomaterials achieve rapid wound healing by preventing desiccation. Hydrogels, ie, a network of hydrophilic polymer chains with water dispersed inside the network, provide an excellent system for wound healing. Polymers, be they from natural origins (eg, polysaccharides and proteoglycans) or synthetic (eg, polyglycolic acid, polylactic acid, polyacrylic acid, poly-?-caprolactone, polyvinyl pyrrolidone, polyvinyl alcohol and polyethylene glycol) exhibit wound healing properties. Micro- and nanoparticulate delivery systems designed with these polymers have also been applied for wound healing. Furthermore, delivering polystyrene particles to the wound surface to induce an inflammatory response is a new concept. This chapter offers an overview of polymer and hydrogels as well as the various novel delivery systems for wound healing with advancements in patents, clinical trials and marketed products.

Original languageEnglish
Title of host publicationFunctional Biomaterials
PublisherElsevier Inc.
Pages203-225
Number of pages23
Volume2
ISBN (Electronic)9780081006061
ISBN (Print)9781782424567
DOIs
StatePublished - 1 Jun 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd All rights reserved.

Keywords

  • Hydrogel
  • Microparticles
  • Nanoparticles
  • Natural polymers
  • Synthetic polymers
  • Wound healing

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