Microbiota at the crossroads of autoimmunity

Oded Shamriz, Hila Mizrahi, Michal Werbner, Yehuda Shoenfeld, Orly Avni, Omry Koren

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations


Autoimmune diseases have a multifactorial etiology including genetic and environmental factors. Recently, there has been increased appreciation of the critical involvement of the microbiota in the pathogenesis of autoimmunity, although in many cases, the cause and the consequence are not easy to distinguish. Here, we suggest that many of the known cues affecting the function of the immune system, such as genetics, gender, pregnancy and diet, which are consequently involved in autoimmunity, exert their effects by influencing, at least in part, the microbiota composition and activity. This, in turn, modulates the immune response in a way that increases the risk for autoimmunity in predisposed individuals. We further discuss current microbiota-based therapies.

Original languageEnglish
Pages (from-to)859-869
Number of pages11
JournalAutoimmunity Reviews
Issue number9
StatePublished - 1 Sep 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.


  • 16S rRNA
  • Autoimmune disease
  • Autoimmunity
  • Bacteria
  • Dysbiosis
  • Inflammatory bowel disease
  • Metagenomics
  • Microbiome
  • Microbiota
  • Psoriasis
  • Rheumatoid arthritis


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